A horror crash on the New England Highway at Wingen on Thursday has turned fatal, with a man losing his fight for life in the John Hunter Hospital.

Police say a Volvo semi-trailer and Toyota Landcruiser towing a caravan collided in the northbound lanes before colliding with an oncoming Izuzu truck.

The truck driver, a 41-year-old man, was freed and flown to the John Hunter Hospital in a critical condition but died early Friday morning.

The Toyota driver, a 63-year-old man, remains in a serious condition, while his 60-year-old female passenger is stable in the John Hunter.

The Volvo driver was treated for shock and taken to hospital for mandatory testing.

Police are appealing for dash cam footage as investigations continue.

The crash scene at Wingen. Picture courtesy NBN News