Police are continuing investigations into a car accident at Clarentown which has claimed the life of a 2-year-old-boy.

At about 9.25 this morning, emergency services were called to the scene at Limeburners Creek Road, near the Bucketts Way.

A truck and Holden Commodore station wagon were involved in the collision and resulted in the small truck carrying boxes and equipment rolling on its side.

The driver of the Holden, a 22-year-old woman was taken to John Hunter Hospital and is in a serious but stable condition.

The two-year-old boy died on the way to the hospital, while a 14-week-old baby boy, also in the Holden has been taken to hospital and has sustained minor injuries and is currently there under observations.

Meanwhile, the male truck driver has also been taken to hospital for minor injuries and will also undergo mandatory blood and urine tests.

Investigations are continuing with police closing Limeburners Creek Road as they prepare a report for the Coroner.