Police are investigating after two men were stabbed at Cliftleigh overnight.

About 1.50am on Friday emergency services were called to a home on Shalistan Street, Cliftleigh, about 20km north-east of Cessnock, following reports two men were fighting and had been stabbed.

On arrival, police found a man, aged in his 20s, with stab wounds to the chest and head.

He was treated at the scene before being taken to John Hunter Hospital. 

He remains in a stable condition.

Police were told a second man left the scene prior to their arrival.

A short time later, police were notified when the 27-year-old man attended Maitland Hospital suffering stab wounds to the chest and neck. 

He was later taken to John Hunter Hospital where he is reported to be in a critical condition.

Officers from Hunter Valley Police District established a crime scene and commenced an investigation into the circumstances surrounding the incident.

Police are conducting a canvass of the area and appealing for anyone with information to come forward.